The mechanisms responsible for the fine tuning of development, where the wildtype phenotype is reproduced with high fidelity, are not well understood. The difficulty in approaching this problem is the identification of mutant phenotypes indicative of a defect in these fine‐tuning control mechanisms. Evolutionary biologists have used asymmetry as a measure of developmental homeostasis. The rationale for this was that, since the same genome controls the development of the left and right sides of a bilaterally symmetrical organism, departures from symmetry (...) can be used to measure genetic or environmental perturbations. This paper examines the relationship between asymmtry and resistance to organophosphorous insecticides in the Australian sheep blowfly, Lucilia cuprina. A resistance gene, Rop‐1, which encodes a carboxylesterase enzyme, also confers a significant increase in asymmetry. Continued exposure of resistant populations to insecticide has selected a dominant suppressor of the asymmetry phenotype. Genetic evidence indicates that the modifier is the L. cuprina Notch homologue. (shrink)

Talks collected from lectures given by Bennett with Gurdjieff's approval, to help people understand All and Everything: Beelzebub's Tales to His Grandson. Bennett regarded Gurdjieff's All and Everything as a work of superhuman genius.

An exploration is given of neural network features now being uncovered in cortical processing which begins to go a little way to help bridge the ''Explanatory Gap'' between phenomenal consciousness and correlated brain activity. A survey of properties suggested as being possessed by phenomenal consciousness leads to a set of criteria to be required of the correlated neural activity. Various neural styles of processing are reviewed and those fitting the criteria are selected for further analysis. One particular processing style, in (...) which semiautonomous and long-lasting cortical activity ''bubbles'' are created by input, is selected as being the most appropriate. Further experimental criteria are used to help narrow the possible neural styles involved. This leads to a class of neural models underpinning phenomenal consciousness and to a related set of testable predictions. (shrink)

This book shines bright light into the dim recesses of quantum theory, where the mysteries of entanglement, nonlocality, and wave collapse have motivated some to conjure up multiple universes, and others to adopt a "shut up and calculate" mentality. After an extensive and accessible introduction to quantum mechanics and its history, the author turns attention to his transactional model. Using a quantum handshake between normal and time-reversed waves, this model provides a clear visual picture explaining the baffling experimental results that (...) flow daily from the quantum physics laboratories of the world. To demonstrate its powerful simplicity, the transactional model is applied to a collection of counter-intuitive experiments and conceptual problems. (shrink)

Copenhagen interpretation of quantum mechanics deals with these problems is reviewed. A new interpretation of the formalism of quantum mechanics, the transactional interpretation, is presented. The basic element of this interpretation is the transaction describing a quantum event as an exchange of advanced and retarded waves, as implied by the work of Wheeler and Feynman, Dirac, and others. The transactional interpretation is explicitly nonlocal and thereby consistent with recent tests of the Bell inequality, yet is relativistically invariant and fully causal. (...) A detailed comparison of the transactional and Copenhagen interpretations is made in the context of well-known quantum-mechanical Gedankenexperimenre and "paradoxes." The transactional interpretation permits quantum-mechanical wave functions to be interpreted as real waves physically present in space rather than as "mathematical representations of knowledge" as in the Copenhagen interpretation. The transactional interpretation is shown to provide insight into the complex character of the quantum-mechanical state vector and the mechanism associated with its "collapse." It also leads in a natural way to justification of the Heisenberg uncertainty principle and the Born probability law (P = ii iij*), basic elements of the Copenhagen interpretation. (shrink)

MIT Press, 1999 Review by Paul Bohan Broderick, Ph.D. on May 26th 2002 Volume: 6, Number: 21.

What is the place of vulnerability in our lives? The current debate about the ethics of enhancement technologies provides a context in which to think about this question. In my view, the current debate is likely to be fruitless, largely because we bring the wrong ethical resources to bear on its questions. In this article, I recall an important, but currently neglected, role that moral concepts play in our thinking, a role they should especially play in relation to the introduction (...) of new technologies. I call this the ‘contemplative role of moral concepts’. I then contrast two approaches to the contemplative role of moral concepts which are found in the current literature, and show why it is important to keep in mind both of these approaches when thinking about human vulnerability. (shrink)

This column is a followup to a previous Alternate View column [Analog, June-'89] about "wormholes", faster-than-light travel, and time machines, which was based on a spectacular theoretical breakthrough in general relativity. It described how a sufficiently advanced civilization might construct a stable wormhole (a curved-space shortcut between one region of space and another) and use it both for faster-than-light travel and for time travel, with no laws of physics violated in the process except causality (the principle that a cause must (...) precede its effects). (shrink)

This column is a milestone. In 1983, while I was on a one year sabbatical at the Hahn Meitner Institute for Nuclear Physics in what was then West Berlin, I received a letter from Stan Schmidt informing me that Jerry Pournelle had decided that he no longer wished to be an Alternate View columnist for Analog and asking if I was interested in taking over as the AV columnist and “alternating” with G. Harry Stine.

The works of Paul K. Feyerabend, Norwood Russell Hanson and Thomas S. Kuhn have come to occupy a central place in the annals of contemporary philosophy of science. Some of their contemporaries,, tend to regard them as the vanguard of a new “revolutionary” intellectual movement. Reacting against the views of their positivist predecessors, they embrace and propagate the idea that “pervasive presuppositions” are fundamental to scientific investigations. Thus, Feyerabend thinks that, “... scientific theories are ways of looking at the world; (...) and their adoption affects our general beliefs and expectations, and thereby also our experiences and our conception of reality”. This is in stark contrast to the positivist view that the aim of science is the systematization of experience that exists independently of any scientific theories. This new view of scientific theories also involves a “radical” conception of the nature of theoretical change. Rejecting the positivist notion of any constant element through such change, Kuhn regards a basic theoretical change as a conceptual revolution and “wants to say that after a revolution scientists are responding to a different world”. Hanson uses the phrase ‘theory-loaded’ to give expression to a view of the semantic content of observation statements that follows from this general position. (shrink)

The plane of the present is a concept that is useful for discussing the various paradigms of time. Here by ‘plane of the present’ we mean the temporal interface that represents the present instant and that forms the boundary between the past and the future. We use the geometrical term ‘plane’ to indicate an extended surface in the space-time continuum, as opposed to a ‘point’ on some time axis. This point/plane dichotomy is intended to raise issues of extension and simultaneity (...) and to examine the degree to which these are meaningful concepts from various physical viewpoints. We will show by example in the present work that the plane of the present is a pivotal concept that offers considerable power in differentiating between various views of the nature of time. The concept of time within the main stream of physics thinking has followed a rather convoluted path over the past three millennia. Anticipating the modern motion picture, Zeno of Elea (c.490-c.430 B.C) questioned whether time should appropriately be viewed as a continuously flowing river, or should more properly be considered as a rapid sequence of stop-motion ‘freeze-frames’, in effect rendering geometrical each instant as a separate infinitesimal point on the line of time. Adopting this view, he asked how physical motion could occur. He argued paradoxically that motion is not possible, since it appears to happen only between the frozen frames of time instants.1 From the viewpoint of Zeno, the plane of the present would be simply the last and most recent in this sequence of freeze-frames. It would be that frozen instant, spanning the universe, which changes progressively as the instant we call ‘now’ becomes the frozen past and future possibility freezes into the ‘now’ of present reality. We note that the plane of the present as a concept does not resolve the arrow paradox that Zeno raised. It only provides a way of thinking about it. (shrink)

Alternate View Column AV-112 Keywords: quantum mechanics entangled states computer computing 7 qubits prime number factoring Schor algorithm NMR nuclear magnetic resonance fast parallel decryption coherence wave-function collapse many-worlds transactional interpretation Published in the June-2002 issue of Analog Science Fiction & Fact Magazine ; This column was written and submitted 12/19/2001 and is copyrighted ©2001 by John G. Cramer.

Maritain's notion of Poetry contains both a creative and a cognitive aspect. His developed epistemology pursues only one of these avenues, however, and leads to his notion of Poetic Knowledge. After tracing the biographical and philosophical influences on Maritain's early development, this dissertation argues that it is possible to reconstruct the undeveloped cognitive aspects of Poetry by gathering the essentially similar insights that are contained in his discussions on the perception of beauty, natural contemplation, and select passages concerning Poetry. The (...) method of obtaining these insights is an historical/theoretical method--by considering Maritain's works from an historical perspective, the theoretical changes and developments are revealed. The development of Maritain's thought is obscured if this method is not employed. With it, however, it is possible to show that early in Maritain's writing career both sides of Aesthetic Exprience are treated by him: the knowledge proper to the creative artist and the knowledge of the one who engages the art-work appreciatively. The latter is discussed by him in his explanation of the perception of beauty. ;As Maritain's ideas develop, a progressive concentration on the knowledge proper to the creative artist occupies his attention with increasing exclusivity, leaving the cognitive aspect of Poetry undeveloped. This study argues that, by discerning the interrelation of Poetry, Beauty, and Contemplation, a reconstructed notion of Poetic Contemplation may be advanced and defended as a legitimate prolongation of Maritain's epistemology. It is a notion which provides a suitable complement to his notion of Poetic Knowledge, and enables us to make sense of that aesthetic experience which possesses a Poetic Intuition but which is not ordered to the production of a work of art, as is the case with Poetic Knowledge, but rather is ordered solely to that joy and delight which characterizes the experience of the beholder. In this fashion a significant contribution is made, not only to Maritainian scholarship, but to the field of Aesthetics as well, since it articulates an aspect of aesthetic experience that previously has not been explored in this detail from within the Thomistic tradition. (shrink)

Last Saturday I made my first journey into virtual reality . I walked with giant strides around a city called Seattle. I leaped the Columbia Center, the tallest building in the city, with a single bound. I dove beneath the surface of Puget Sound and watched a pod of whales heading north toward Canada. I hovered above the Space Needle, then dropped inside to enjoy its panoramic view and to examine its structural details. I raced a Washington State ferry across (...) the Sound from Seattle to Bremerton. I caught up with it just as it approached the Bremerton dock and was able to watch the docking operation from a perch on the roof of the bridge. Then I flew back across the Sound and peered down into the Kingdome, looking in vain for a winning team. Finally, I pointed my magic glove across the Sound to the Olympic Peninsula, flew there, and examined a group of towering snow-capped peaks from all angles. I did all of this without leaving a small building on the campus of the University of Washington. (shrink)

Two years ago, astrophysicists studying Type Ia supernovas discovered that our universe is a much stranger place than we had imagined, with invisible vacuum energy accelerating its expansion. (See my column about this in the May-1999 Analog.) However, new astrophysical observations from the BOOMERanG experiment (Balloon Observations Of Millimetric Extragalactic Radiation and Geomagnetics), a balloon-borne cryogenic microwave telescope measurement that flew at an altitude of about 24 miles over the Antarctic, indicate that our universe is also rather ordinary, in that (...) its space is maximally flat. The term “flat” as used here means that the space of our universe is neither positively curved like a ball or negatively curved like a potato chip. It appears that in our universe, the tendencies of space toward positive curvature from gravitational attraction and towards negative curvature from expansion kinetic energy are precisely in balance, leaving space on the average completely free of curvature. (shrink)

My previous Alternate View column (ANALOG 9/84) described the widely accepted "inflationary scenario" of modern cosmology in which our Universe is just one among very many "bubble universes", all popping out of the general medium of the Big Bang like bubbles forming in a glass of beer. Somewhere perhaps there are many universes more or less like ours, some very similar to and others radically different from the universe we call "home".

I'm sure you know the plot: a lost magical formula has eluded the wisest practitioners of the arcane art down through the ages. Now a cabal of young upstarts, with disdain for conventional wisdom and working against all odds, discovers the key ingredients that make the magic spell work, with spectacular results.

The territory of time travel has, from the days of H. G. Wells to the mid-1980's, been the exclusive province of writers of science fiction and fantasy. SF critics have even argued that time travel stories are so scientifically unlikely that they should be considered fantasy, not science fiction.

Although the work consists of sixteen connected chapters, there is a difference of motivation that led to the book being published in two volumes. The first eleven chapters, comprising Volume I, attempt to teach good guessing through examples. The remaining chapters, in Volume II, deal with general principles of plausible reasoning.

The dimensional framework -- The dramatic universe -- Function, being and will -- The conditions of existence -- The threshold of existence -- Natural knowledge of God.